{"id":1278,"date":"2023-07-18T16:17:13","date_gmt":"2023-07-18T16:17:13","guid":{"rendered":"https:\/\/mitogendx.com\/?post_type=faq&#038;p=1278"},"modified":"2025-07-22T13:17:19","modified_gmt":"2025-07-22T19:17:19","slug":"mypatient-is-receiving-ivig-intravenous-immunoglobulin-treatment-does-this-affectthe-results-of-the-autoantibody-and-related-serology-test-results","status":"publish","type":"faq","link":"https:\/\/mitogen.dev5.oracastdev.com\/fr\/faq\/mypatient-is-receiving-ivig-intravenous-immunoglobulin-treatment-does-this-affectthe-results-of-the-autoantibody-and-related-serology-test-results\/","title":{"rendered":"My patient is receiving IVIG (intravenous immunoglobulin) treatment. Does this affect the results of the autoantibody and related serology test results?"},"content":{"rendered":"<p>Intravenous immunoglobulin (IVIG) therapy is a commonly used treatment for various autoimmune and inflammatory diseases. IVIG is a preparation of pooled human immunoglobulin G (IgG) derived from thousands of blood donors (4, 5). Natural antibodies and even some autoantibodies are prominent in these preparations. While IVIG therapy has significant benefits in managing some autoimmune\/autoinflammatory conditions, it is important to be aware of its potential effects on autoantibody and inflammatory disease lab tests.<br \/>\nAutoantibody testing plays a crucial role in diagnosing and monitoring autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, autoimmune neurological diseases, and many others. IVIG therapy can affect results in several ways:<\/p>\n<ul>\n<li>IVIG contains a wide range of antibodies that can compete with the patient\u2019s autoantibodies during lab testing. This competition may lead to lower detectable levels of autoantibodies, potentially resulting in false negative results. Typically, IVIG affects the sensitivity but not the specificity of an autoantibody test (6).<\/li>\n<li>IVIG preparations can contain certain autoantibodies (7-9). This may lead to detectable levels of autoantibodies, potentially resulting in false positive results.<\/li>\n<li>Temporary suppression of autoantibody production: IVIG therapy can transiently suppress the production of autoantibodies, particularly in patients with active autoimmune diseases.<\/li>\n<li>This effect may lead to a decrease in autoantibody levels. If autoantibody levels(titers) are being used to follow-the disease course (remission or flares) this can be helpful feature to gauge effective response of IVIG.<\/li>\n<li>Interference with Specific Autoantibody Assays: Some autoantibody assays utilize techniques that may be affected by the presence of IVIG. For example, enzyme-linked immunosorbent assays (ELISAs) may exhibit non-specific binding or interference due to the high IgG concentration in IVIG preparations. Laboratories should be advised if a patient has received IVIG treatment so that methods can be used to minimize false positive or false negative results.<\/li>\n<li>Transient impact on Other\u00a0Inflammatory Markers: IVIG therapy can transiently affect various inflammatory markers, including acute phase reactants (i.e., CRP, ESR), cytokines, chemokines, complement and adhesion molecules. These changes may be related to the immunomodulatory effects of IVIG and can result in factitious fluctuations of the laboratory test results. It is important to consider the timing of patient sampling when interpreting these markers.<\/li>\n<li>Interference with Immunological Assays: IVIG contains a variety of immunoglobulins, which may interfere with specific immunological assays used to measure cytokines, chemokines, complement or other inflammatory markers.<\/li>\n<\/ul>\n<p><strong>SUMMARY:<\/strong>\u00a0IVIG has a complex effect on autoantibody and other biomarker lab test results. Healthcare professionals should be aware of these effects when they interpret test results and make informed clinical decisions. Close collaboration between clinicians and laboratory specialists is essential to navigate the challenges posed by IVIG therapy and ensure optimal patient care in the context of autoimmune and inflammatory diseases.<\/p>\n<p><strong>RECOMMENDATION:<\/strong>\u00a0If the patient is already receiving IVIG and there is a need to do autoantibody or related biomarker testing, it is best to draw the serum or plasma sample immediately PRIOR to the next IVIG infusion. This can be a helpful approach to determining the impact and efficacy of IVIG in reducing autoantibodies and other molecules that are considered pathogenic that may be correlated with the clinical course (i.e., remission or flares) of the disease.<\/p>\n","protected":false},"template":"","class_list":["post-1278","faq","type-faq","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>My patient is receiving IVIG (intravenous immunoglobulin) treatment. Does this affect the results of the autoantibody and related serology test results? - MitogenDx<\/title>\n<meta name=\"description\" content=\"Learn how IVIG treatment may impact autoantibody and serology test results. 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